An older woman named Liana suffers from excruciating pain in her sinuses and blindness in her left eye. A mass in her sinuses appear to be a malignant tumor, but when Liana blows some strange-looking tissue out of her nose, it turns out she actually has a fungal infection called aspergillosis. A young single mother named Robin deals with breathing difficulties, coughing, fatigue, and body aches from a rare inflammatory disease called Churg Strauss Syndrome, which causes her to lose her job and home. Every year, millions of Americans fall prey to real-life medical mysteries ailments that go undiagnosed or misdiagnosed for years. Their lives are thrown into turmoil as medical professionals struggle to understand their baffling conditions. Mystery diagnosis tells their stories. Through interviews and dramatic recreations, each medical mystery is recounted in vivid detail. Symptoms emerge, specialists are called in, but still the daily struggle continues. And then one day, because of a patients relentless pursuit of an accurate diagnosis, or a forward thinking doctor, the problem is solved and a true diagnosis given.
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