What are the factors that tell the immune system, this is not safe, and that is tissue damage. So, the immune system is basically saying, "I will make a decision about this. To make this decision, I need data." So, what are the data that things are okay? Retinoic acid, prostaglandin E2. What are the data that say this is not okay? All the factors released during tissue damage because tissue damage is the number one sign that something is harmful. If the thing comes in and they're fine, then the next time they take it, they don't tolerate it. That sounds like they are programmed to decide that everything that comes in is a threat. And so they take it, and it gets into their system and it doesn't do anything, but meanwhile the immune system took a piece of that into gut-associated lymphoid tissue, and said, "We need to program to make an army against this threat," and so it's the second time that they took it that they have the reaction.
Get the arachidonic acid, get rid of the anti-inflammatories, get the retinoic acid from the vitamin A, and thoroughly investigate any possible sources of tissue damage in the gut. So, those are the things that I would be looking at.
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